Triphenylphosphine → HCID 58216786, compound

Participants

Role	Name	HCID	Charge
Reactant	Triphenylphosphine	HCID 11776	—
Reactant	Methyl (2-hydroxyphenyl)acetate	HCID 89719	—
Reactant	Di-tert-butyl diazene-1,2-dicarboxylate	HCID 6034084	—
Reactant	1-(4-Hydroxypiperidin-1-yl)ethan-1-one	HCID 10749291	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 58216786	HCID 58216786	55.8%

Reaction Conditions

Temperature	20 °C

Reaction Steps

Di-tert-butylazodicarboxylate (305 mg, 1.32 mmol) was dropped to a solution of 1-(4-hydroxy-piperidin-1-yl)-ethanone (259 mg, 1.8 mmol) in tetrahydrofuran (4 mL) under nitrogen atmosphere. Then (2-hydroxy-phenyl)-acetic acid methyl ester (200 mg, 1.2 mmol) and triphenylphosphine (347 mg, 1.3 mmol) were added. The yellow mixture was stirred at 20° C. for 16 h. The solvent was evaporated and the residue was purified on silica using hexane/ethyl acetate mixture of increasing polarity (from 70% to 100% ethyl acetate) as eluent to give 195 mg (55.6%) of a colourless oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08623901B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-63c1c31b1d664103aea4e5a2344698d0
Source note	uspto-grants-2014_01