反应详情

Under inert atmosphere a solution of 500 mg (3.783 mmol) of 2-Aminophenylacetonitrile and 1 mL (7.566 mmol) of 2,5-Dimethoxytetrahydrofuran in 5 mL of acetic acid was heated to 60° C. for 2 hours. After cooling the reaction mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on SiO2 using cyclohexane/ethyl acetate mixture of increasing polarity (from 100% cyclohexane to 100% ethyl acetate) as eluent. The title compound was obtained as a light yellow oil (470 mg, 68.2%).

1. temperatureAfter cooling the reaction mixture
2. concentrationwas concentrated under reduced pressure
3. customThe residue was purified by flash chromatography on SiO2
4. additioncyclohexane/ethyl acetate mixture
5. temperatureof increasing polarity (from 100% cyclohexane to 100% ethyl acetate) as eluent