Latanoprost → HCID 178459547, compound

Participants

Reaction Steps

To Latanoprost free acid (CAS #41639-83-2) (1, 21.2 mg, 0.054 mmol) in MeOH/H2O (4:1, 0.65 mL) was added L-Arginine (>98%, Sigma-Aldrich, St. Louis, Mo.). (72 mM solution in MeOH/H2O [4:1]) (754 μL, 0.054 mmol) and the solution was stirred for 30 minutes. The solvents were evaporated then azeotroped with Et2O and hexanes to give white crystalline Latanoprost-L-Arginine salt 2 (quantitative).

Provenance & Evidence