HRID468034

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CC(C)OC(=O)CCC/C=C\C[C@@H]1[C@@H](CC[C@@H](O)CCc2ccccc2)[C@H](O)C[C@@H]1O$

HCID5311221

Latanoprost

C26H40O5

HCID178418600

未命名化合物

PRODUCTS

生成物

$结构：CC(C)OC(=O)CCC/C=C\C[C@@H]1[C@@H](CC[C@@H](O)CCc2ccccc2)[C@H](O)C[C@@H]1O.N=C(N)NCCC[C@H](N)C(=O)O$

HCID178459547

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID22242641

Methanol--water (1/1)

CH6O2

PROCEDURE

实验过程

To Latanoprost (free acid) (1, 21.2 mg, 0.054 mmol) in MeOH/H2O (4:1, 0.65 mL) was added L-Arginine (72 mM solution in MeOH/H2O [4:1]) (754 μL, 0.054 mmol) ((>98%) from Sigma-Aldrich Cat. A5006) and the solution was stirred for 30 minutes. The solvents were evaporated then azeotroped with Et2O and hexanes to give white crystalline Latanoprost-L-Arginine salt 2 (quantitative).

WORKUP

后处理

customThe solvents were evaporated
customthen azeotroped with Et2O and hexanes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f9db36b4bb72452ba9bc607472ecf2c6
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08623918B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH3:1][CH:2]([O:4][C:5]([CH2:7][CH2:8][CH2:9]/[CH:10]=[CH:11]\[CH2:12][C@@H:13]1[C@@H:17]([CH2:18][CH2:19][C@@H:20]([OH:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C@H:16]([OH:30])[CH2:15][C@@H:14]1[OH:31])=[O:6])[CH3:3].[NH2:32][C@H:33]([C:41]([OH:43])=[O:42])[CH2:34][CH2:35][CH2:36][NH:37][C:38](=[NH:40])[NH2:39]>CO.O>[CH3:3][CH:2]([O:4][C:5]([CH2:7][CH2:8][CH2:9]/[CH:10]=[CH:11]\[CH2:12][C@@H:13]1[C@@H:17]([CH2:18][CH2:19][C@@H:20]([OH:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C@H:16]([OH:30])[CH2:15][C@@H:14]1[OH:31])=[O:6])[CH3:1].[NH2:32][C@H:33]([C:41]([OH:43])=[O:42])[CH2:34][CH2:35][CH2:36][NH:37][C:38](=[NH:39])[NH2:40]