反应详情

A mixture of 28.5 g. (0.11 mole) of 3-tert. butyl-4-phenyl isoquinoline, 2.85 g. platinum oxide and 300 ml. of acetic acid is hydrogenated at room temperature and 50 psi until two equivalents of hydrogen are absorbed. The catalyst is filtered off and the acetic acid is evaporated in vacuo. The residue is dissolved in ether, washed with 50% sodium hydroxide, water and saturated sodium fluoride solution, dried over magnesium sulfate, filtered and evaporated. The residue is crystallized from petroleum ether to give 3-tert.butyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline; m.p. 79°-81° C.

1. additionA mixture of 28.5 g
2. customis hydrogenated at room temperature
3. filtrationThe catalyst is filtered off
4. customthe acetic acid is evaporated in vacuo
5. dissolutionThe residue is dissolved in ether
6. washwashed with 50% sodium hydroxide, water and saturated sodium fluoride solution
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered
9. customevaporated
10. customThe residue is crystallized from petroleum ether