HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Methyl 3-phenyl-1H-indole-6-carboxylate TFA salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-tert-Butyl 6-methyl 3-phenyl-1H-indole-1,6-dicarboxylate | HCID 59626044 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-phenyl-1H-indole-6-carboxylate TFA salt | HCID 131731077 | — |
Reaction Steps
To a solution of 1-tert-butyl 6-methyl 3-phenyl-1H-indole-1,6-dicarboxylate 62b (4.04 mmol, 1.42 g) in CH2Cl2 (8 mL) was added 6 mL of TFA. The resulting solution was stirred for 3 h. The mixture was then concentrated and washed with hexanes to afford 62c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623858B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-85529fa3bdef4f5ca6d0e22be33ace62 |
| Source note | uspto-grants-2014_01 |