反应详情

A mixture of 5-bromomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g), N-methylpiperazine (1.17 g) in isopropyl alcohol (15 ml) was refluxed for 6 hours. After evaporating the solvent, the residue was dissolved in chloroform, washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The filtrate was evaporated under reduced pressure, and the residue was subjected to column chromatography on alumina (100 g) eluting with chloroform. The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from diethyl ether to give 6-methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine. (0.30 g).

1. temperaturewas refluxed for 6 hours
2. customAfter evaporating the solvent
3. dissolutionthe residue was dissolved in chloroform
4. washwashed with saturated aqueous sodium chloride
5. dry with materialdried over magnesium sulfate
6. customThe filtrate was evaporated under reduced pressure
7. washeluting with chloroform
8. additionThe fractions containing the object compound
9. concentrationconcentrated under reduced pressure
10. customThe residue was recrystallized from diethyl ether