反应详情

A mixture of 5-(1-bromoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g) and N-methylpiperazine (1.13 g) in isopropylalcohol (15 ml) was refluxed for 1.5 hours. The reaction mixture was evaporated in vacuo. The residue was chromatographed on allumina eluting with a mixture of ethyl acetate and n-hexane (1:20). The fractions containing the desired product were combined and concentrated in vacuo. The residue was crystallized from a mixture of n-hexane and diethyl ether to give 6-methyl-5-[1-(4-methylpiperazin-1-yl)ethyl]-4-(3-nitrophenyl)-2-phenylpyrimidine (0.51 g).

1. temperaturewas refluxed for 1.5 hours
2. customThe reaction mixture was evaporated in vacuo
3. customThe residue was chromatographed on allumina
4. additioneluting with a mixture of ethyl acetate and n-hexane (1:20)
5. additionThe fractions containing the desired product
6. concentrationconcentrated in vacuo
7. customThe residue was crystallized from a mixture of n-hexane and diethyl ether