1-Propanol, 3-[[2-nitro-4-(trifluoromethyl)phenyl]amino]- → 3-{[2-Amino-4-(trifluoromethyl)phenyl]amino}-1-propanol

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Reaction Steps

A mixture of 141 parts of 3-{[2-nitro-4-(trifluoromethyl)phenyl]amino}-1-propanol and 1200 parts of methanol is hydrogenated at normal pressure and at room temperature with 15 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized from 2,2'-oxybispropane, yielding 110 parts (100%) of 3-{[2-amino-4-(trifluoromethyl)phenyl]amino}-1-propanol.

Provenance & Evidence