HCID 51356773, compound → HCID 57518386, compound

HRID 468559Notes

Reaction equation

HRID 468559 reaction equation
N([C@H:4]([CH2:9][C:10]1[CH:15]=[C:14]([F:16])[C:13]([F:17])=[CH:12][C:11]=1[F:18])[CH2:5][C:6](O)=[O:7])=[N+]=[N-].N1C=CN=N1>>[F:18][C:11]1[CH:12]=[C:13]([F:17])[C:14]([F:16])=[CH:15][C:10]=1[CH2:9][CH2:4][CH2:5][CH:6]=[O:7]

Participants

3

Reactant 2

HCID 51356773HCID 51356773, compoundHCID 178418936HCID 178418936, compound

Product 1

HCID 57518386HCID 57518386, compound

Procedure

In step (iv), (3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid of formula (IV) obtained in step (iii) is subjected to a condensation reaction with a triazol derivative of formula (VI) to obtain (3R)-3-azido-1-(3-trifluoromethyl)-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)-butan-1-one of formula (V).

Sources & evidence

ORD record
ord-f408dfc1a5d34591aa74dc1ef5f9ab18
Source dataset
uspto-grants-2014_01
Patent number
US08624026B2

Reaction notes

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