Sodium Hydroxide → HCID 53375443, compound

HRID 468561Notes

Reaction equation

HRID 468561 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH2:10][C@H:11]([OH:14])[CH2:12]Cl.[OH-].[Na+]>CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[CH2:10][C@H:11]1[CH2:12][O:14]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54764462HCID 54764462, compound

Product 1

HCID 53375443HCID 53375443, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(2S)-3-(2,4,5-trifluorophenyl)-1-chloro-2-propanol obtained in step 1 was dissolved in methanol (50 ml), and NaOH (2.3 g) was added dropwise thereto. The resulting mixture was stirred for 1 hour and methanol was removed therefrom under a reduced pressure. Water (50 ml) and ethyl acetate (50 ml) were added to the resulting mixture, and the organic layer formed thereafter was separated. The separated organic layer was washed with satuated saline, dried over MgSO4, and filtered to remove MgSO4. The organic solvent was removed from the filtrate under a reduced pressure to obtain the title compound (6.8 g; yield: 80%).

Workup

  1. custommethanol was removed
  2. additionWater (50 ml) and ethyl acetate (50 ml) were added to the resulting mixture
  3. customthe organic layer formed
  4. customthereafter was separated
  5. washThe separated organic layer was washed with satuated saline
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. customto remove MgSO4
  9. customThe organic solvent was removed from the filtrate under a reduced pressure

Sources & evidence

ORD record
ord-973b88b1251a4aa0b01f03fe8a20bc10
Source dataset
uspto-grants-2014_01
Patent number
US08624026B2

Reaction notes

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