HRID468576

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O

HCID4493

Nilutamide

C12H10F3N3O4

结构：CC1(C)C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)N1CCCCCN1C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)C1(C)C

HCID46937259

未命名化合物

PRODUCTS

生成物

结构：CC1(C)C(=O)N(c2ccc([N+](=O)[O-])cc2C(F)(F)F)C(=O)N1CCCCCN1C(=O)N(c2ccc([N+](=O)[O-])cc2C(F)(F)F)C(=O)C1(C)C

HCID49764093

未命名化合物

收率 12%

PROCEDURE

实验过程

The experimental protocol used is the same as that described for the synthesis of the compound of Example 2, intermediate 11.1 replacing 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-imidazolidine-2,4-dione. The expected compound is obtained in the form of a light yellow foam with a yield of 12%.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6b46cc2190e94b52989a804d67020e88
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08624037B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH2:1]([N:28]1[C:32]([CH3:34])([CH3:33])[C:31](=[O:35])[N:30]([C:36]2[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[C:38](C(F)(F)F)[CH:37]=2)[C:29]1=[O:49])[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[C:16](C(F)(F)F)[CH:15]=2)[C:7]1=[O:27].CC1(C)NC(=O)N(C2C=CC([N+]([O-])=O)=C([C:66]([F:69])([F:68])[F:67])C=2)C1=O>>[CH2:1]([N:28]1[C:32]([CH3:33])([CH3:34])[C:31](=[O:35])[N:30]([C:36]2[CH:37]=[CH:38][C:39]([N+:42]([O-:44])=[O:43])=[CH:40][C:41]=2[C:66]([F:69])([F:68])[F:67])[C:29]1=[O:49])[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][C:15]=2[C:66]([F:69])([F:68])[F:67])[C:7]1=[O:27]