HCID 46937259, compound → HCID 66752400, compound

HRID 468577Notes

Reaction equation

HRID 468577 reaction equation
[CH2:1]([N:26]1[C:30]([CH3:32])([CH3:31])[C:29](=[O:33])[N:28]([C:34]2[CH:39]=[CH:38][C:37]([NH2:40])=[C:36]([C:41](F)(F)F)[CH:35]=2)[C:27]1=[O:45])[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[C:16]([C:21](F)(F)F)[CH:15]=2)[C:7]1=[O:25].C(N1C(C)(C)C(=O)N(C2C=CC([N+]([O-])=O)=C(C)C=2)C1=O)CCCCN1C(C)(C)C(=O)N(C2C=CC([N+]([O-])=O)=C(C)C=2)C1=O.C(N1C(C)(C)C(=O)N(C2C=CC([N+]([O-])=O)=C(C(F)(F)F)C=2)C1=O)CCCCN1C(C)(C)C(=O)N(C2C=CC([N+]([O-])=O)=C(C(F)(F)F)C=2)C1=O>>[CH2:5]([N:6]1[C:10]([CH3:12])([CH3:11])[C:9](=[O:13])[N:8]([C:14]2[CH:19]=[CH:18][C:17]([NH2:20])=[C:16]([CH3:21])[CH:15]=2)[C:7]1=[O:25])[CH2:4][CH2:3][CH2:2][CH2:1][N:26]1[C:30]([CH3:32])([CH3:31])[C:29](=[O:33])[N:28]([C:34]2[CH:39]=[CH:38][C:37]([NH2:40])=[C:36]([CH3:41])[CH:35]=2)[C:27]1=[O:45]

Participants

4

Reactant 3

HCID 46937259HCID 46937259, compoundHCID 49764091HCID 49764091, compoundHCID 49764092HCID 49764092, compound

Product 1

HCID 66752400HCID 66752400, compoundYield 69%

Procedure

The experimental protocol used is the same as that described for the synthesis of the compound of Example 8 starting from the compound of Example 10, which replaces the compound of Example 2. The expected compound is obtained in the form of a white foam with a yield of 69%.

Sources & evidence

ORD record
ord-108e6c62b0044c3f832bf5962e5b6cc0
Source dataset
uspto-grants-2014_01
Patent number
US08624037B2

Reaction notes

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