3-Bromo-1,1,1-trifluoro-2-propanone → HCID 86657118, compound

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Reaction Steps

In a 250 ml round-bottomed flask equipped with condenser and magnetic stirrer, a solution of methyl 2-[4-(carbamothioylamino)phenyl]propanoate (10.7 g, 48.4 mmol) in 1,4-dioxane (200 ml) was treated at room temperature with 3-bromo-1,1,1-trifluoro-propan-2-one (5 ml, 48.4 mmol) and the reaction mixture was refluxed for 2 h. After cooling at room temperature, the solvent was distilled under vacuum, the residue dissolved in CH2Cl2 (200 ml), washed with a saturated solution of NaHCO3 (3×100 ml), dried over anhydrous Na2SO4 and evaporated under vacuum to give pure methyl 2-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)propanoate (12.8 g, 38.7 mmol) as yellow oil (80%).

Provenance & Evidence