Bromopinacolone → HCID 45111067, compound

Participants

Reaction Steps

Following the same procedure described for 1 and starting from methyl 2-[4-(carbamothioylamino)phenyl]propanoate (2.49 g, 10 mmol) and 1-bromopinacolone (1.75 ml, 13 mmol), after workup and methyl ester hydrolysis, pure compound 6 (1.75 g, 5.7 mmol) was isolated by filtration (38% overall yield from methyl 2-[4-(carbamothioylamino)phenyl]propanoate).

Provenance & Evidence