p-Toluenesulfonic acid → HCID 67215909, compound

Participants

Reaction Steps

To a stirred solution of THP-protected hydroxy ester 5 (1 g, 2.53 mmol) in methanol (35 ml) was added p-TsOH (30 mg, 1 mg/ml). The reaction mixture was stirred at room temperature for 1 hr, concentrated and diluted with EtOAc. Organic layer was washed twice with NaHCO3 and water, dried over MgSO4, filtered and concentrated. The obtained oily residue (712 mg, 90%) was used for next step without further purification.

Provenance & Evidence