反应详情

A mixture of 5-(3-benzoylthioureidomethyl)-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.0 g) and sodium hydroxide (0.089 g) in methanol (20 ml) and water (10 ml) was stirred for 1 hour at a room temperature. After evaporating the solvent, water (20 ml) was added thereto and stirred for 30 minutes. The resulting precipitates were collected by filtration, washed with water and dried over phosphorous pentoxide to give 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-thioureidomethylpyrimidine (0.75 g).

1. customAfter evaporating the solvent, water (20 ml)
2. additionwas added
3. stirringstirred for 30 minutes
4. customThe resulting precipitates
5. filtrationwere collected by filtration
6. washwashed with water
7. dry with materialdried over phosphorous pentoxide