Hydrochloric Acid → HCID 70664571, compound

Participants

Reaction Steps

Lithium hydroxide (108 mg, 4.37 mmol) was added to a solution of ethyl (2R)-4-[4-(4-ethoxyphenyl)-5-fluoro-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)butanoate (320 mg, 0.728 mmol) in tetrahydrofuran:water (1:1, 20 mL) and the reaction was allowed to stir at rt until complete. The reaction mixture was acidified with 4 M aq HCl and extracted with EtOAc. The combined organic layers were dried (MgSO4), filtered and concentrated to afford the title compound as a solid (220 mg, 73%). MS (LCMS) m/z 412.2 (M+1). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.26-1.40 (m, 3H) 1.54 (s, 3H) 2.07-2.26 (m, 1H) 2.43 (d, J=6.24 Hz, 1H) 3.14 (s, 3H) 3.83-4.15 (m, 4H) 6.42 (d, J=7.81 Hz, 1H) 6.93-7.07 (m, 2H) 7.50 (dd, J=8.68, 1.85 Hz, 2H) 7.97 (d, J=6.83 Hz, 1H).

Provenance & Evidence