反应详情

A solution of ethyl 5-benzyl-7,7-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (14.6 g, 0.044 mol) in anhydrous DCM was cooled to 0° C. whereupon K2CO3 (6.1 g, 0.044 mmol) and α-chloroethyl chloroformate (6.97 g, 0.049 mol) were added. Upon complete addition, the reaction was heated at reflux overnight. The reaction was cooled to room temperature and diluted with DCM, then washed with saturated aqueous NaHCO3 and brine respectively. The organic layer was dried over anhydrous Na2SO4 and evaporated to afford an oily residue which was taken up in EtOH and refluxed for 2 hours. The solvent was evaporated to dryness and the residue was washed with ethyl acetate to afford the desired product (9.6 g, 79%). 1H NMR (400 MHz, DMSO) δ 9.82 (s, 2H), 7.64 (s, 1H), 4.28 (q, J=7.2 Hz, 2H), 4.15 (s, 2H), 3.26 (s, 2H), 1.42 (s, 6H), 1.28 (t, J=7.2 Hz, 3H).

1. additionwere added
2. additionUpon complete addition
3. temperaturethe reaction was heated
4. temperatureat reflux overnight
5. washwashed with saturated aqueous NaHCO3 and brine respectively
6. dry with materialThe organic layer was dried over anhydrous Na2SO4
7. customevaporated
8. customto afford an oily residue which
9. temperaturerefluxed for 2 hours
10. customThe solvent was evaporated to dryness
11. washthe residue was washed with ethyl acetate