HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 4-methoxy-N,2,6-trimethyl-N-[(4-{[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 4-(Pyrrolidin-1-ylmethyl)piperidine | HCID 16768347 | — |
| Reactant | 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid | HCID 58393097 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-methoxy-N,2,6-trimethyl-N-[(4-{[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide | HCID 58393004 | — |
Reaction Steps
The title compound was prepared according to general procedure AG using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (60 mg, 0.17 mmol), EDCI (33 mg, 0.17 mmol), HOAt (24 mg, 0.17 mmol and 4-(pyrrolidin-1-ylmethyl)piperidine (28 mg, 0.17 mmol) in DMF (1 mL). The crude product was purified by FCC and then using prep method C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623859B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-f0d6ecb5889a4c78b5ce233cf4aa7421 |
| Source note | uspto-grants-2014_01 |