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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 469024Generated: October 30, 2026

1,1'-Carbonyldiimidazole → HCID 58393182, compound

https://huagongshe.com/reaction/469024

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
ReactantDiisopropylethylamineHCID 81531—
Reactant5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acidHCID 58393097—
ReactantHCID 58393152HCID 58393152—
Solvent1,2-DichloroethaneHCID 11—
ProductHCID 58393182HCID 58393182—

Reaction Steps

The title compound was prepared according to general procedure AE using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (60 mg, 0.15 mmol), CDI (51 mg, 0.31 mmol), DIPEA (0.134 mL, 0.76 mmol) and N4-[4-(2-aminoethyl)phenyl]pyrimidine-2,4-diamine (49 mg, 0.15 mmol) in DCE (1 mL). A portion of the crude product was purified using prep method A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08623859B2
Source datasetuspto-grants-2014_01
ORD IDord-bff49af1485e4529817af809ceacf73b
Source noteuspto-grants-2014_01