1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 58392965, compound

Participants

Reaction Steps

The title compound was prepared according to General Procedure AC using 3-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-thiadiazole-5-carboxylic acid (120 mg, 0.32 mmol), 2-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]ethanamine bis-trifluoroacetate (133 mg, 0.32 mmol), EDCI, (76.8 mg, 0.4 mmol), HOBt (54.4 mg, 0.4 mmol) and DIPEA (0.097 mL, 0.96 mmol) in DMF (5 mL). After stirring at ambient temperature for 42 h the reaction was concentrated and the crude product was purified using prep method C, affording the title compound.

Provenance & Evidence