Aluminium lithium hydride → HCID 58393156, compound

Participants

Reaction Conditions

Reaction Steps

tert-butyl[3-fluoro-5-(pyrrolidin-1-ylmethyl)benzyl]carbamate (0.72 mmol) was dissolved in anhydrous THF (2 mL) under N2 and the solution was cooled to 0° C. LiAlH4 (1 M in THF, 1.62 mL) was added and the reaction was stirred at between 0° C. and 40° C. for 40 h. The reaction was partitioned between 1:1 saturated aqueous NaHCO3: 30% aqueous Rochelle's salt (20 mL) and DCM (3×15 mL) and the combined organic extracts were dried over MgSO4 and concentrated in vacuo to afford the title compound as a yellow oil. No further purification was required.

Provenance & Evidence