反应详情

The title compound was prepared according to general procedure AN using tert-butyl 2-{[2-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3-oxazol-4-yl]carbonyl}octahydro-5H-pyrrolo[3,4-c]pyridine-5-carboxylate (245 mg, 0.42 mmol), TFA (1 mL) and DCM (3 mL). Following the completion of the reaction the solvent was removed in vacuo, the residue redissolved in DCM (2 mL), absorbed on to 2 g SCX cartridge and washed with DCM (5 mL) and MeOH (5 mL). The title compound was eluted with 7 N NH3 in MeOH (10 mL) and concentrated in vacuo.

1. customthe completion of the reaction the solvent
2. customwas removed in vacuo
3. dissolutionthe residue redissolved in DCM (2 mL)
4. customabsorbed on to 2 g SCX cartridge
5. washwashed with DCM (5 mL) and MeOH (5 mL)
6. washThe title compound was eluted with 7 N NH3 in MeOH (10 mL)
7. concentrationconcentrated in vacuo