Toluene → HCID 46175825, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of ethyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](cyclopropyl)amino}methyl)-1,3-oxazole-2-carboxylate (25 mg, 0.07 mmol) and 1-(N-methylpiperidin-4-yl-methyl)piperazine (26 mg, 0.13 mmol) in DCE (1 mL) was added trimethylaluminium 2M in toluene (65 μL, 0.13 mmol) and the mixture stirred at 60° C. for 1.5 h. The reaction mixture was washed with saturated aqueous NaHCO3 and extracted with DCM. The organic extract was dried over MgSO4, and concentrated in vacuo. The residue was purified by FCC eluting with 95:4.5:0.5 NH3/MeOH/DCM. This afforded the title compound as a colourless oil.

Provenance & Evidence