化工社化工社 化学情報印刷レポート · 研究参考用
1-(2-pyrrolidin-1-ylethyl)piperazine → Ammonia
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-pyrrolidin-1-ylethyl)piperazine | HCID 2737250 | — |
| 反応物 | Trimethylaluminum | HCID 16682925 | — |
| 反応物 | Ethyl 3-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl] (methyl)amino}methyl)-1,2,4-oxadiazole-5-carboxylate | HCID 58393145 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | HCID 46175724 | HCID 46175724 | — |
反応手順
The title compound was prepared according to general procedure AT using ethyl 3-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-oxadiazole-5-carboxylate (30 mg, 0.08 mmol), 1-[2-(pyrrolidin-1-yl)ethyl]piperazine (29 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623859B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-cfef7b8cc2ec476d9046486b0aede08b |
| 出典メモ | uspto-grants-2014_01 |