1-[(1-Methylpiperidin-3-yl)methyl]piperazine → Ammonia

Participants

Reaction Steps

The title compound was prepared according to general procedure AT using ethyl 3-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,2,4-oxadiazole-5-carboxylate (30 mg, 0.07 mmol), 1-[(1-methylpiperidin-3-yl)methyl]piperazine (31 mg, 0.14 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). A portion of the crude product was purified using prep method C, then FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.

Provenance & Evidence