HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Pyrrolidinopropyl)Piperazine → 4-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Pyrrolidinopropyl)Piperazine | HCID 2737252 | — |
| Reactant | Trimethylaluminum | HCID 16682925 | — |
| Reactant | Ethyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-oxadiazole-3-carboxylate | HCID 58393139 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 4-Methoxy-N,2,6-trimethyl-N-[(3-{[4-(3-pyrrolidin-1-ylpropyl)piperazin-1-yl]carbonyl}-1,2,4-oxadiazol-5-yl)methyl]benzenesulfonamide | HCID 58393282 | — |
Reaction Steps
The title compound was prepared according to general procedure AT using ethyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,2,4-oxadiazole-3-carboxylate (27 mg, 0.07 mmol), 1-[3-(pyrrolidin-1-yl)propyl]piperazine (40 mg, 0.20 mmol) and trimethylaluminium (2 M in toluene, 0.08 mL) in DCE (2 mL). A portion of the crude product was purified using prep method D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08623859B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-3deb2db89e5c47fc9b9272b5b3a67b1c |
| Source note | uspto-grants-2014_01 |