Trifluoroacetic acid → HCID 58069237, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-6-chloro-5-[4-(methylsulfonyl)phenyl]pyrazine-2-carboxylic acid (0.18 mmol, 60 mg,), 4-(dimethylamino)phenyl boronic acid (0.24 mmol, 40 mg), tetrakis(triphenylphosphine) Pd(0) (0.033 mmol, 38 mg), cesium carbonate (2.1 mmol, 297 mg) in dimethylformamide (2 ml) and deionized water (0.4 ml) was mixed under argon at room temperature. The reaction was heated in a microwave reactor at 120° C. for 15 min. The product was characterized by LC-MS (5-50 acetonitrile with 0.1% trifluoroacetic acid, positive ion [M+H]+=413).

Provenance & Evidence