HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | 6-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methyl)quinoline | HCID 46911863 | — |
| Solvent | Water ethylacetate | HCID 22728543 | — |
| Product | 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide | HCID 58955250 | — |
Reaction Steps
Methanesulphonate (mesylate) salt of the compound of formula (I) (8.7 g) is dissolved in ethyl acetate/water mixture (50/50 vol/vol; 400 mL). Addition of sodium carbonate (2.5 g) liberates the free base form of the compound of formula (I) which crystallises from the solvent mixture. The solids are filtered, washed and dried at 50° C. to provide 6.53 g of Form III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629144B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-59e24965c87a4a1fa2b3e825440f74db |
| Source note | uspto-grants-2014_01 |