HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Sodium difluoro(quinolin-6-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2,2-difluoro-2-(quinolin-6-yl)acetate | HCID 28242385 | — |
| Solvent | Water | HCID 962 | — |
| Product | Sodium difluoro(quinolin-6-yl)acetate | HCID 59439326 | — |
Reaction Steps
8.1 g (32.2 mmol) of ethyl difluoro(quinolin-6-yl)acetate was added to a reaction balloon. Methanol (40.5 mL) and water (2.9 mL) were added. To this solution, 1.29 g sodium hydroxide (32.2 mmol) was added at room temperature for 16 h. The resulting solids were filtered off and dried under vacuum. Yield 4.5 g (18.4 mmol; 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629144B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c836e622dbf44dfebddc01ef07ad7d22 |
| Source note | uspto-grants-2014_01 |