HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 469227Generated: October 25, 2026
Water → ethyl (2E)-3-[7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]acrylate
https://huagongshe.com/reaction/469227
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Triethyl phosphonoacetate | HCID 13345 | — |
| Reactant | HCID 86633051 | HCID 86633051 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | ethyl (2E)-3-[7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]acrylate | HCID 66636880 | — |
Reaction Steps
1.0 g of 7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbaldehyde was dissolved in 20 ml of DMF, and 2.0 g of potassium carbonate and 2.8 ml of ethyl(diethoxyphosphoryl)acetate were added, followed by overnight stirring at 60° C. The resulting reaction mixture was cooled to room temperature, water was added, and then the insoluble materials were collected by filtration to obtain 1.2 g of ethyl (2E)-3-[7-(cyclohexylamino)-1-cyclopentyl-6-fluoro-4-oxo-1,4-dihydroquinolin-3-yl]acrylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08629126B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-90681219f6314f828a51c4c0826f4c56 |
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| Source note | uspto-grants-2014_01 |
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