反应详情

A solution of 2-bromo-3-(4-methoxybenzylmercapto) propanoic acid (15 g.), methylmercaptan (3 g.) and sodium hydroxide (4.6 g.) in 95% ethanol (25 ml.) is refluxed for twelve hours. The sodium bromide is filtered off and the filtrate is concentrated to dryness in vacuo. The residue is dissolved in water, acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness to yield 3-(4-methoxybenzylmercapto)-2-(methylthio)propanoic acid.

1. filtrationThe sodium bromide is filtered off
2. concentrationthe filtrate is concentrated to dryness in vacuo
3. dissolutionThe residue is dissolved in water
4. extractionextracted with ethyl acetate
5. customThe organic layer is dried
6. concentrationconcentrated to dryness