反应详情

温度

130 °C

A well stirred mixture of 2.34 g (13.2 mmol) 6-chloropyrimidine-4-carboxylic acid chloride, 8.00 g (60.0 mmol) aluminium trichloride and 1.79 g (12.0 mmol) 4-methyl-3H-benzoxazol-2-one was heated to 130° C. for 1.5 h. After cooling to RT the mixture was decomposed with ice water, then extracted with ethyl acetate, the organic phase was dried on sodium sulphate and evaporated down i. vac. The crude product left as a solid was triturated with diethyl ether, suction filtered and dried in the air.

1. temperatureAfter cooling to RT the mixture
2. extractionextracted with ethyl acetate
3. customthe organic phase was dried on sodium sulphate
4. customevaporated down i
5. waitThe crude product left as a solid
6. customwas triturated with diethyl ether, suction
7. filtrationfiltered
8. customdried in the air