HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methyl dicyclohexylamine → 5-bromo-7-methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methyl dicyclohexylamine | HCID 24210 | — |
| Reactant | 5-Bromo-7-methyl-1H-indazole | HCID 1382033 | — |
| Reactant | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-bromo-7-methyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazole | HCID 58181208 | — |
Reaction Steps
1.95 mL (11.0 mmol) (2-chloromethoxy-ethyl)-trimethyl-silane were added to 2.11 g (10.0 mmol) 5-bromo-7-methyl-1H-indazole and 1.80 mL (12.3 mmol) N-methyldicyclohexylamine in 50 mL THF and stirred overnight at RT. The precipitate formed was filtered off and the filtrate was evaporated down. The residue was purified by flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629137B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-bb0ef38bd3d1402b842c1a6df6a14b57 |
| Source note | uspto-grants-2014_01 |