反应详情

2.08 g (9.48 mmol) 3-bromo-benzoic acid chloride, 1.41 g (9.48 mmol) 4-methyl-3H-benzoxazol-2-one and 5.33 g (40.0 mmol) aluminium trichloride were heated to 125° C. with stirring for 1.5 h. Then the mixture was mixed with ice water and the grease precipitated was separated from the solvent by decanting. The residue was dissolved in EtOAc, evaporated down and a little MeOH was triturated. The precipitate formed was suction filtered, washed with diethyl ether and dried i. vac.

1. customthe grease precipitated
2. customwas separated from the solvent
3. customby decanting
4. dissolutionThe residue was dissolved in EtOAc
5. customevaporated down
6. customa little MeOH was triturated
7. customThe precipitate formed
8. filtrationfiltered
9. washwashed with diethyl ether
10. customdried i