反应详情

2.23 g (9.40 mmol) 3-bromo-4-fluoro-benzoic acid chloride, 1.40 g (9.40 mmol) 4-methyl-3H-benzoxazol-2-one and 5.01 g (37.60 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered and washed with water. Then the precipitate was triturated with MeOH, suction filtered, washed with MeOH and dried i. vac.

1. customThe precipitate formed
2. filtrationfiltered
3. washwashed with water
4. customThen the precipitate was triturated with MeOH, suction
5. filtrationfiltered
6. washwashed with MeOH
7. customdried i