HCID 59856533, compound → HCID 59856531, compound

Participants

Reaction Steps

13.7 g (38.8 mmol) 3-(1-benzyl-piperidin-4-yl)-9-fluoro-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one in 100 mL MeOH were shaken with 2.00 g palladium on charcoal (Pd/C 10%) under a hydrogen atmosphere (3 bar) at RT. The catalyst was filtered off and the solvent was evaporated down. The residue was purified by flash chromatography. The fractions containing the product were combined and evaporated down. The residue was stirred with DIPE/EtOAc, suction filtered and dried.

Provenance & Evidence