HRID469417

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c(OCc5ccccc5)c(C)c4)ncn3)CC1)C(=O)N2

HCID58181128

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c(O)c(C)c4)ncn3)CC1)C(=O)N2

HCID58181109

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

70 mg (0.10 mmol) 3-{1-[6-(4-benzyloxy-3,5-dimethyl-benzoyl)-pyrimidin-4-yl]-piperidin-4-yl}-7-methoxy-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one and 20 mg palladium on charcoal (Pd/C 10%) in 10 mL MeOH were hydrogenated for 30 min at RT in a hydrogen atmosphere of 10 psi. After filtration of the reaction mixture the solvent was eliminated i. vac. and the residue was purified by preparative HPLC-MS. The fractions containing the product were combined and freeze-dried.

WORKUP

后处理

filtrationAfter filtration of the reaction mixture the solvent
customand the residue was purified by preparative HPLC-MS
additionThe fractions containing the product
customfreeze-dried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-10e91efbf6d64abda2b86c8b3b4c99c1
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08629137B2
来源说明: uspto-grants-2014_01

反应 SMILES

C([O:8][C:9]1[C:42]([CH3:43])=[CH:41][C:12]([C:13]([C:15]2[N:20]=[CH:19][N:18]=[C:17]([N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:33][CH2:32][C:31]5[CH:34]=[C:35]([O:38][CH3:39])[CH:36]=[CH:37][C:30]=5[NH:29][C:28]4=[O:40])[CH2:23][CH2:22]3)[CH:16]=2)=[O:14])=[CH:11][C:10]=1[CH3:44])C1C=CC=CC=1.[H][H]>[Pd].CO>[OH:8][C:9]1[C:42]([CH3:43])=[CH:41][C:12]([C:13]([C:15]2[N:20]=[CH:19][N:18]=[C:17]([N:21]3[CH2:22][CH2:23][CH:24]([N:27]4[CH2:33][CH2:32][C:31]5[CH:34]=[C:35]([O:38][CH3:39])[CH:36]=[CH:37][C:30]=5[NH:29][C:28]4=[O:40])[CH2:25][CH2:26]3)[CH:16]=2)=[O:14])=[CH:11][C:10]=1[CH3:44]