Cesium carbonate → 3-{1-[5-(3,4-Dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-2-fluoro-phenyl]-piperidin-4-yl}-7-methoxy-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one

Participants

Reaction Conditions

Reaction Steps

Under an argon atmosphere 330 mg (1.20 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one, 437 mg (1.20 mmol) 6-(3-bromo-4-fluoro-benzoyl)-3,4-dimethyl-3H-benzoxazol-2-one and 586 mg (1.80 mmol) caesium carbonate were combined in 10 mL dioxane, then mixed with 75 mg (0.12 mmol) BINAP and 27 mg (0.12 mmol) palladium(II)acetate and stirred for 48 h at 100° C. The mixture was evaporated down, the residue was dissolved in DMF/MeOH and purified by preparative HPLC-MS. The fractions containing the product were combined and the acetonitrile was evaporated down. The aqueous residue was made basic with 1N aqueous sodium hydroxide solution, the precipitate formed was suction filtered and washed with water and dried. As the product was still contaminated, it was then purified again by preparative HPLC-MS.

Provenance & Evidence