Trifluoroacetic acid → HCID 58181103, compound

Participants

Reaction Steps

0.50 mL TFA were added to 57 mg (0.10 mmol) tert-butyl[4′-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-6′-yl]-carbamate in 5.00 mL DCM and stirred for 3 h at RT. Then another 0.50 mL TFA were added and the mixture was stirred overnight at RT. Then the reaction mixture was evaporated down, the residue was dissolved in DMF and purified by preparative HPLC-MS. The fractions containing the product were combined and freeze-dried.

Provenance & Evidence