反应详情

1.00 mL TFA were added to 59 mg (0.096 mmol) tert-butyl[4′-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazole-6-carbonyl)-4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-6′-yl]-methyl-carbamate in 5.00 mL DCM and the mixture was stirred for 3 h at RT. Then the reaction mixture was evaporated down, the residue was dissolved in DMF and purified by preparative HPLC-MS. The fractions containing the product were combined and freeze-dried.

1. customThen the reaction mixture was evaporated down
2. dissolutionthe residue was dissolved in DMF
3. custompurified by preparative HPLC-MS
4. additionThe fractions containing the product
5. customfreeze-dried