反应详情

温度

100 °C

Benzo[b]thiophen-3-ylboronic acid (387 mg, 2.17 mmol), aniline (202 mg, 2.17 mmol), and 2-oxoacetic acid hydrate (200 mg, 2.17 mmol) were dissolved in acetonitrile (12 ml) and then stirred at 100° C. under microwave irradiation for 1 hour. The solvent was evaporated, and the residue was dissolved in EtOAc and washed with sat.NaHCO3. 2N HCl was added to the aqueous phase until pH was about 7, and the product was extracted with EtOAc. The organic phase was dried with Na2SO4, filtered and evaporated to obtain 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetic acid (295 mg, 48% yield).

1. customThe solvent was evaporated
2. dissolutionthe residue was dissolved in EtOAc
3. washwashed
4. addition2N HCl was added to the aqueous phase until pH was about 7
5. extractionthe product was extracted with EtOAc
6. dry with materialThe organic phase was dried with Na2SO4
7. filtrationfiltered
8. customevaporated