Diethyl Ether → HCID 54765172, compound

Participants

Reaction Steps

2-Chloro-1-(thiophen-2-yl)ethanone (32.7 mg, 0.20 mmol) was added to a solution of (R)—((R)-quinuclidin-3-yl) 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate (diastereomer 1 of C19) (80 mg, 0.20 mmol) in EtOAc (3 ml). The reaction was stirred at r.t. overnight. Diethylether (10 ml) was added, and the precipitate was collected and dried under vacuum to obtain (R)-3-((R)-2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (101 mg, 90% yield).

Provenance & Evidence