2-Chloroacetophenone → HCID 86660324, compound

Participants

Reaction Steps

2-Chloro-1-phenylethanone (98 mg, 0.64 mmol) was added to a solution of (R)—((R)-quinuclidin-3-yl) 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate (diastereomer 1 of C19) (250 mg, 0.64 mmol) in CH3CN (3 ml). The reaction mixture was stirred at r.t. overnight, and then the solvent was evaporated and the residue was triturated with Et2O. The crude was purified by preparative HPLC (Eluent: CH3CN/H2O), to obtain (R)-3-((R)-2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (210 mg, 60.3% yield).

Provenance & Evidence