Diethyl Ether → HCID 86660325, compound

Participants

Reaction Steps

To a solution of (S)—((R)-quinuclidin-3-yl) 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate (diastereomer 2 of C19) (62 mg, 0.16 mmol) in ethyl acetate (3 ml), was added 2-chloro-1-(thiophen-2-yl)ethanone (25.4 mg, 0.16 mmol), and the reaction mixture was stirred at r.t. overnight. Diethyl ether (10 ml) was added, and the precipitate was filtered and dried under vacuum to obtain (R)-3-((S)-2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-(thiophen-2-yl)ethyl)-1-azoniabicyclo[2.2.2]octane chloride (75 mg, 86% yield).

Provenance & Evidence