2-Chloroacetophenone → HCID 86660326, compound

Participants

Reaction Steps

A solution of (S)—((R)-quinuclidin-3-yl) 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate (diastereomer 2 of C19) (230 mg, 0.586 mmol) and 2-chloro-1-phenylethanone (91 mg, 0.586 mmol) in dry CH3CN (2 ml) was stirred at r.t. for 24 hours. Then the solvent was evaporated and the residue was purified by preparative HPLC (Eluent: CH3CN/H2O) to obtain (R)-3-((S)-2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride (102 mg, 31.8% yield).

Provenance & Evidence