HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 2-(Benzo[b]thiophen-7-yl)-2-(phenylamino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 1-Benzothien-7-ylboronic acid | HCID 16640528 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(Benzo[b]thiophen-7-yl)-2-(phenylamino)acetic acid | HCID 58557038 | 63.7% |
Reaction Steps
A mixture of benzo[b]thiophen-7-ylboronic acid (300 mg, 1.68 mmol), aniline (157 mg, 1.68 mmol), and 2-oxoacetic acid hydrate (155 mg, 1.68 mmol) in CH3CN (20 ml) was stirred at room temperature for 2 hours. The solvent was evaporated and the crude was purified by flash chromatography (DCM/MeOH=9/1) to obtain 2-(benzo[b]thiophen-7-yl)-2-(phenylamino)acetic acid (303 mg, 63.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629160B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-b0b765b6764c4e89aa545c36aae88dc5 |
| Source note | uspto-grants-2014_01 |