HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 58556986, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | (1-Benzothiophen-3-yl)boronic acid | HCID 2776344 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58556986 | HCID 58556986 | 60.7% |
Reaction Steps
A mixture of benzo[b]thiophen-3-ylboronic acid (300 mg, 1.68 mmol), phenylmethanamine (184 μl, 1.68 mmol) and 2-oxoacetic acid hydrate (155 mg, 1.68 mmol) in acetonitrile (20 ml) was stirred at room temperature for 2 hours. The solvent was removed and crude was triturated with Et2O/CH3CN (9/1) to obtain 2-(benzo[b]thiophen-3-yl)-2-(benzylamino)acetic acid (303 mg, 60.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629160B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-dbd72fbb2af145e6aa11022e16828ef0 |
| Source note | uspto-grants-2014_01 |