Phenacyl bromide → HCID 86660330, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-1-phenylethanone (44.8 mg, 0.22 mmol) and (R)-quinuclidin-3-yl 2-(benzo[b]thiophen-3-yl)-2-(2-ethylphenylamino)acetate (C44) (86 mg, 0.20 mmol) in EtOAc (3 ml) was heated under microwave irradiation at 100° C. for 1 hour. 2-Bromo-1-phenylethanone (44.8 mg, 0.22 mmol) was added, and the mixture was heated at 100° C. under microwave irradiation for an additional hour. The solvent was evaporated, and the crude product was triturated with Et2O to collect (3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(2-ethylphenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide (44.6 mg, 35.2% yield).

Provenance & Evidence